Research Paper
Year: 2018 | Month: April-June | Volume: 2 | Issue: 2 | Pages: 19-24
Synthesis, Characterization and Application of Mannich Base
Rashmi Bhardwaj1, Poonam Parihar2, Komal Yadav3, NB Bardhan4
2Assistant Professor, 1,2Department of Chemistry, IIS University, Jaipur, Rajasthan, India
3Research Scholar, 4Director, CFSL/CBI/New Delhi
Corresponding Author: Komal Yadav
ABSTRACT
A Mannich base from the reaction of p-chlorobenzaldehyde, acetophenone and p-toluidine was obtained by using EtAlCl2 as catalyst. The formation of this mannich base is an organic reaction which consists of amino alkylation of an acidic proton placed next to a carbonyl group by formaldehyde and a primary or secondary amine, and then the final product formed is a β-amino-carbonyl compound known as Mannich base. Here we have taken p-chlorobenzaldehyde in place of formaldehyde and p-toluidine as an amine. This reaction is known as Mannich reaction. The compound formed from this reaction was then duly characterized on the basis of IR, 1H-NMR studies; strong bonds of the compounds are shown in the spectras. And then, biological screening was carried out against E.coli and staphylococcus aureus and the compound was found to be active against E.Coli and staphylococcus aureus. The Mannich-Reaction is employed in the organic synthesis of natural compounds such as peptides, nucleotide, antibiotics, and alkaloids (e.g. tropinone). Other applications are in agro chemicals such as plant growth regulators, paint- and polymer chemistry. As the formed compound was biologically active so it can be used as a pharmaceutical product also. So we can say that the compound formed by using p-chlorobenzaldehyde, acetophenone, and p-tolouidine was found to be a biologically active compound on E.coli and staphylococcus aureus. And it was also concluded that EtAlCl2 can also be used as a catalyst for synthesizing a Mannich base as it was proved in this reaction that by using EtAlCl2 as a catalyst a compound i.e a Mannich base can be synthesized successfully and its properties are also mentioned below and also its biological applications were also found..
Key words: Mannich base, β-amino-carbonyl compound, p-toluidine, EtAlCl2
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